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Adhesive biomaterial platform

Our fully biodegradable and highly biocompatible adhesive material platform allows us to overcome the challenges associated with commercially-available materials.
 

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Our adhesive material (green) is able to sense tissue surface (red)chemistry and provide optimal adhesion while maintaining the maximal biocompatibility in multiple tissue types and states.

Vascular sealant

Our vascular adhesive consists of a two-component kit that can be sprayed or delivered using a dual-barrel syringe. Its biocompatibility has been tested according to the ISO-10993-5 guidelines, confirming its excellent biocompatibility. 

Preclinical porcine studies confirmed the superior performance of our material compared to commercially available sealants. Its synthetic nature affords low cost and safe manufacturing.

Commercial vascular sealant

BioDevek vascular sealant

No recovery 14-day post-surgery

Adequate vessel recovery

The clips display 5-6mm swine carotids 14 days after an ePTFE graft placement. Carotid vessel narrowing owing to blood occlusion during the procedure was significant. BioDevek provided excellent sealing and biocompatibility that was evident by the ability of the vessel to recover to its original dimensions. The commercial sealant that was used as a control did not support  vessel recovery as shown by the decreased luminal diameter with a compromised blood flow. 

Endoscopic application

We developed a sealant formulation that can be sprayed through catheters during an endoscopic procedure to seal and protect wounds following polyp resection and other minimally-invasive surgeries. Our sealant creates a thin, but tough, tissue-like coating that minimizes the risk of perforation and late-bleeding events. 

Colonoscopy screening accompanied by polyp resection, has risen during the last decade as the most efficient method to prevent colorectal cancer, which is the third leading cause of cancer deaths among American men and women. Over 20 million colonoscopies are performed annually in the US.

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The use of BioDevek hydrogel on the wound following polyp resection creates a mechanical barrier, reinforcing the integrity of the intestinal wall. Its adhesive nature creates an intimate interdigitation with the tissue, protecting it and avoiding delayed bleeding. The hydrogel shield also acts as a barrier, minimizing the exposure of the wound to the intestinal content, protecting the area from bacteria, enzymes, and mechanical damage, thus enhancing the overall healing process.

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Publications

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